Antifungal medicines - Interactions with other medicines

When two or more medicines are taken at the same time, the effects of one of the medicines can be altered by the other. This is known as a drug-drug interaction. Some antifungal medicines can interact with other medicines.

Tell your GP or pharmacist what other medicines you are taking, including over-the-counter medicines, so they can decide whether an antifungal medicine is safe for you to take.

Medicines that antifungal medicines may interact with include:

• benzodiazepines – a group of medicines used to help sleep and reduce anxiety
• ciclosporin – a medicine that suppresses the immune system (the body’s natural defence against illness and infection)
• cimetidine – a medicine used to treat indigestion
• hydrochlorothiazide – a medicine used to treat high blood pressure (hypertension) 
• oestrogens – hormones found in some contraceptives
• phenytoin – a medicine used to treat epilepsy
• progestogens - hormones found in some contraceptives
• rifampicin – an antibiotic used to treat bacterial infections, such as tuberculosis 
• tacrolimus – a medicine that suppresses the immune system
• theophylline – a medicine used to treat asthma
• tricyclic antidepressants – medicines used to treat depression
• zidovudine – a medicine used to treat HIV and AIDS